Valley of forgetting Alzheimer's families and the search for a cure
"The riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer's disease In the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For...
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| Format: | Books Print Book |
| Language: | English |
| Published: |
New York :
Riverhead Books,
2025.
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| LEADER | 00000cam a22000008i 4500 | ||
|---|---|---|---|
| 001 | on1456541024 | ||
| 003 | OCoLC | ||
| 005 | 20260106171400.0 | ||
| 008 | 240920s2025 nyu b 001 0 eng | ||
| 010 | |a 2024044615 | ||
| 020 | |a 9780525536079 |q (hardcover) | ||
| 020 | |a 0525536078 |q (hardcover) | ||
| 020 | |z 9780525536093 |q (ebook) | ||
| 035 | |a (OCoLC)1456541024 | ||
| 040 | |a DNLM/DLC |b eng |e rda |c DLC |d IG# |d OCLCO |d BRL |d IMT |d GO3 |d IUK |d MJ8 |d OCLCO |d DYJ |d VP@ | ||
| 042 | |a pcc | ||
| 050 | 0 | 0 | |a RC523 |
| 060 | 0 | 0 | |a WT 155 |
| 082 | 0 | 0 | |a 362.1968/311 |2 23/eng/20241115 |
| 092 | |a 362.1968/311 | ||
| 100 | 1 | |a Smith, Jennie Erin, |d 1973- |e author. | |
| 245 | 1 | 0 | |a Valley of forgetting : |b Alzheimer's families and the search for a cure / |c Jennie Erin Smith. |
| 246 | 3 | |a Alzheimer's families and the search for a cure | |
| 264 | 1 | |a New York : |b Riverhead Books, |c 2025. | |
| 300 | |a 376 pages ; |c 24 cm | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a unmediated |b n |2 rdamedia | ||
| 338 | |a volume |b nc |2 rdacarrier | ||
| 504 | |a Includes bibliographical references (pages 355-366) and index. | ||
| 505 | 0 | |a Curious doctors -- Las familias -- Resilience. | |
| 520 | |a "The riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer's disease In the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer's disease. Over the next forty years of working with the "paisa mutation" kindred, he went on to build a world-class research program in a region beset by violence and poverty. In Valley of Forgetting, Jennie Erin Smith brings readers into the clinic, the laboratories, and the Medellín trial center where Lopera's patients receive an experimental drug to see if Alzheimer's can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones' brains to science and subjected themselves to invasive testing to help uncover how Alzheimer's develops and whether it can be stopped. Findings from this unprecedented effort could hold the key to understanding and treating the disease, though it is unclear what, if anything, the families will receive in return. Smith's immersive storytelling brings this complex drama to life, inviting readers on a scientific journey that is as deeply moving as it is engrossing"-- |c Provided by publisher. | ||
| 650 | 0 | |a Alzheimer's disease. | |
| 600 | 1 | 0 | |a Restrepo Lopera, Francisco, |d 1951-2024. |
| 650 | 0 | |a Medicine |x Research. | |
| 650 | 0 | |a Medicine, Experimental. | |
| 651 | 0 | |a Colombia. | |
| 776 | 0 | 8 | |i Online version: |a Smith, Jennie Erin, 1973- |t Valley of forgetting |d New York : Riverhead Books, [2025] |z 9780525536093 |w (DLC) 2024044616 |
| 994 | |a C0 |b PCB | ||
| 949 | |a CCL |b CadNF |c 362.1968 Sm |d i |e 39241503869815 |f 793644 |g ddc |j 04/08/2025 | ||
| 949 | |a HOLT |b HadNF |c 362.1968 Sm |d i |e 39241503869823 |f 793645 |g ddc |j 04/08/2025 | ||
| 999 | |a 500182 | ||
